| | | Friday, January 21st, 2011 | | Signed free agent C Luis Oliveros to a 2-year contract worth a total of $1,140,000. |
| Wednesday, December 1st, 2010 | | Drafted 1B Travis Metcalf in the 2010 Rule 5 Draft (Round 1, Pick 12, 12th overall Pick), from the Colorado Rockies. | | Drafted SP Graham Taylor in the 2010 Rule 5 Draft (Round 2, Pick 12, 42nd overall Pick), from the Florida Marlins. | | Lost CL Adam Miller in the Rule 5 Draft to the Los Angeles Angels. | | Drafted 2B Jim Negrych in the 2010 Rule 5 Draft (Round 3, Pick 12, 72nd overall Pick), from the Pittsburgh Pirates. | | Drafted SS Andy Gonzalez in the 2010 Rule 5 Draft (Round 4, Pick 12, 102nd overall Pick), from the Baltimore Orioles. |
| Sunday, November 28th, 2010 | | 1B Russell Branyan becomes a free-agent. | | SP Mitch Talbot received a 1-year contract through automatic renewal worth a total of $400,700. | | MR Chris Perez received a 1-year contract through automatic renewal worth a total of $402,000. | | MR Tony Sipp received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Justin Masterson received a 1-year contract through automatic renewal worth a total of $415,500. | | RF Brian Barton received a 1-year contract through automatic renewal worth a total of $600,000. | | C Lou Marson received a 1-year contract through automatic renewal worth a total of $400,000. | | 3B Lonnie Chisenhall received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Grant Balfour becomes a free-agent. | | C Carlos Santana received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Aaron Laffey received a 1-year contract through automatic renewal worth a total of $408,700. | | CL Jess Todd received a 1-year contract through automatic renewal worth a total of $400,000. | | 1B Matt LaPorta received a 1-year contract through automatic renewal worth a total of $400,000. | | LF Michael Brantley received a 1-year contract through automatic renewal worth a total of $400,000. | | C Steve Holm received a 1-year contract through automatic renewal worth a total of $400,000. | | 3B Mat Gamel received a 1-year contract through automatic renewal worth a total of $400,000. | | 1B Jordan Brown received a 1-year contract through automatic renewal worth a total of $400,000. | | 2B Luis Valbuena received a 1-year contract through automatic renewal worth a total of $400,300. | | LF Trevor Crowe received a 1-year contract through automatic renewal worth a total of $400,000. | | LF Nick Weglarz received a 1-year contract through automatic renewal worth a total of $400,000. | | SS Carlos Rivero received a 1-year contract through automatic renewal worth a total of $400,000. | | SP David Huff received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Wilton Lopez received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Jason Grilli becomes a free-agent. | | C Damaso Espino becomes a free-agent. | | RF Austin Kearns becomes a free-agent. | | CF Justin Christian becomes a free-agent. | | C Chris Gimenez becomes a free-agent. |
| Thursday, November 25th, 2010 | | MR Joe Smith received a 1-year contract through arbitration worth a total of $1,930,500. | | SP Luke Hochevar received a 1-year contract through arbitration worth a total of $1,800,000. | | 2B Anderson Hernandez received a 1-year contract through arbitration worth a total of $600,000. | | RF Shin-Soo Choo received a 1-year contract through arbitration worth a total of $6,835,500. | | MR Brandon Medders becomes a free-agent. | | MR Ramon S. Ramirez received a 1-year contract through arbitration worth a total of $1,302,000. |
| Saturday, November 6th, 2010 | | Signed MR Jensen Lewis to a 2-year contract extension worth a total of $3,000,000. |
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